2025 Nedbank Cup Last 16 Draw was conducted in Randburg at Supersport Studios.
The draw results were as follows :-
Durban City vs TS Galaxy
Orlando Pirates vs Baroka FC
Kaizer Chiefs vs Chippa United
Mamelodi Sundowns vs Mpheni Home Defenders
Marumo Gallants vs AmaZulu FC
Milford FC or Royal AM vs Sekhukhune United
Stellenbosch FC vs Polokwane City FC
Supersport United vs Cape Town Spurs
Dates, venues, kick-off times and ticket information will be confirmed in due course by the Premier Soccer League.
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